ICare Indicated Prevention

WP leader David Daniel Ebert, Matthias Berking (FAU)

Contact   Website


The aim of this work-package is develop an individually tailored indicated transdiagnostic intervention for the prevention of depression and anxiety and to test its effectiveness and cost-effectiveness of guided and unguided versions in individuals with subclinical symptoms of depression and anxiety.

Depression and Anxiety are the most prevalent mental disorders and often co-occur. Prevention efforts have so far focused on disorderspecific psychological interventions. This trial will be among the first that will evaluate whether a single transdiagnostic intervention can prevent Depression and Anxiety Disorders (Panic, Social Phobia, Generalized Anxiety) and whether this is possible using an Internet-based self-help intervention.

The “ICare indicated prevention” model will be compared to existing health care system models without access to interventions for subclinical symptoms (care-as-usual = CAU). The trial will be conducted in 4 countries (Germany, Switzerland, Spain, the Netherlands). All study sites will apply an identical design and similar procedure, allowing the pooling of data across countries in order to achieve more statistical power.

Specific objectives are:

  • To provide online interventions for common mental health disorders (Depression, Panic Disorder, Social Phobia, Generalized Anxiety Disorder) for individuals with subclinical symptoms.
  • To evaluate the (cost)-effectiveness of guided and unguided versions of ICare-IP for reducing the onset of CMHD in at-risk individuals compared with care-as-usual. Additionally, we will assess the comparative effectiveness and acceptability of guided and unguided ICare-IP on disorder specific course of symptoms and other relevant secondary outcome criteria.
> >